6 Mp

Mercaptopurine is a medication classified as an immunosuppressant and antimetabolite, commonly used in the treatment of various conditions, including acute lymphoblastic leukemia (ALL), inflammatory bowel disease (IBD), and autoimmune disorders like rheumatoid arthritis. As an antimetabolite, mercaptopurine works by disrupting the synthesis of DNA and RNA in rapidly dividing cells, particularly cancer cells, thus inhibiting their growth and proliferation. In the treatment of ALL, mercaptopurine is often used as part of combination chemotherapy regimens to induce remission and prevent relapse. In patients with IBD, such as Crohn’s disease and ulcerative colitis, mercaptopurine helps to suppress the overactive immune response that causes inflammation in the gastrointestinal tract, thereby reducing symptoms and promoting remission.

One of the key features of mercaptopurine is its ability to selectively target rapidly dividing cells, including cancer cells and activated immune cells, while sparing normal, healthy cells. This targeted mechanism of action helps to minimize side effects and toxicity associated with the medication, although some individuals may experience adverse effects such as bone marrow suppression, liver toxicity, and gastrointestinal disturbances. Additionally, mercaptopurine therapy requires careful monitoring of blood counts and liver function to ensure safety and efficacy. Despite these potential risks, mercaptopurine plays a vital role in the treatment of certain cancers and autoimmune disorders, offering patients a chance at remission and improved quality of life.