Chloroquine, a venerable antimalarial drug, has garnered renewed attention for its potential benefits in combating various ailments beyond malaria. Its multifaceted properties extend beyond its primary function, showcasing promising outcomes in diverse medical arenas. From its historical role as a stalwart against malaria to its emerging applications in autoimmune diseases like lupus and rheumatoid arthritis, Chloroquine exhibits a spectrum of therapeutic effects. Moreover, recent research highlights its antiviral properties, suggesting potential efficacy against infectious diseases such as COVID-19 by impeding viral replication and modulating immune responses. Beyond its pharmacological prowess, Chloroquineâ€™s affordability and widespread availability underscore its significance as a global health asset, particularly in resource-limited settings where access to advanced therapeutics may be constrained. However, caution is warranted regarding its side effects and appropriate dosing, necessitating vigilant clinical management to optimize its therapeutic benefits while mitigating potential risks.